膜性粘蛋白翻译后修饰
汪荣泉，男，主任医师，教授，消化研究所所长，博士生导师。加拿大多伦多大学博士后，从医20余年，具有丰富的临床经验，主要从事膜性粘蛋白翻译后修饰的研究。任中华消化学会青年委员，中华消化学会胃肠激素组成员。获军队科技进步和医疗成果奖二等奖各1项，重庆市自然科学奖1项。承担国家自然科学基金2项，教育部归国人员启动基金1项。已发表学术论文50余篇，其中在国外杂志发表7篇，SCI收录论文10篇。发表论文主要如下：1、Effects of Helicobacter pylori infection on mucin expression in gastric carcinoma and pericancerous tissues. Journal of Gastroenterology and Hepatology (2006) 21, 425–431 2、Rodent IRR-219 (IgGFcγ BP) and rTFF3, expressed mainly in the intestinal mucosa, depleted during dextran sulfate sodium–induced colitis. Dig Dis and Sci (DOI 10.1007/s10620-006 3、C-terminal domain of rodent intestinal mucin Muc3 is proteolytically cleaved in the endoplasmic reticulum to generate extracellular and membrane components. Biochem J 2002; 366:623-631 4、Alterations of MUC1 and MUC3 expression in gastric carcinoma:relevance to patient clinicopathological features. J Clin Pathol 2003;56:378-384 5、SEA(sea-urchin sperm protein,enterokinase and agrin)-module cleavage,association of fragments and membrane targeting of rat intestinal mucin Muc3. Biochem J 2003;372:263-270 6、N-linked oligosaccharides play a role in disulphide-dependent dimerization of intestinal mucin Muc2. Biochem J 2003;373:893-900 7、Evidence for a second peptide cleavage in the C-termianl domain of rodent intestinal mucin Muc3. Biochem J (submitted) 8、Aberrant expresson of MUC2 and MUC3 genes in gastric carcinoma and its significance. Chin Med J 2000;113:502-507 9、Detection of hepatitis C virus core, NS3 and NS5 antigens in liver tissues of hepatocellular carcinoma patients. Chin Med J 1998;111:407 10、Mutation and methylation of Hmlh1 in gastric carcinomas with microsatellite instability. World J Gastroenterol 2003;9(4):645-649 11、Effect of HCV infection on expression of several cancer-associated gene products in HCC. World J Gastroenterol. 1999 Feb;5(1):25-27.
